Discuss the molecular biology of antigenic shift in influenza viruses

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Discuss the molecular biology of antigenic shift in influenza viruses and comment on the immunological consequences for the host. Why does antigenic shift prevent the production of a single universally effective vaccine for influenza control? Next, compare antigenic shift to antigenic drift. Which causes the greatest antigenic change? Which creates the biggest problems for vaccine developers? Which can lead to pandemic influenza, and why?

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